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Oncology

New pathways to cancer therapyA novel oral formulation of itraconazole (SUBA-Itraconazole, HedgePath Pharmaceuticals) is providing dramatic benefit for patients with basal cell carcinoma nevus syndrome (BCCNS, also known as Gorlin syndrome) and with a favorable safety profile, according to a recent interim analysis of data collected in a phase IIb study.
Skin cancer screeningData-driven screening guidelines for skin cancer have been published electronically, in reaction to the U.S. Preventive Services Task Force’s 2016 draft recommendation statement on skin cancer screening.
ECP may prevent mycosis fungoides progressionExtracorporeal photopheresis is underused for early-stage mycosis fungoides. ECP is capable of correcting the cytokine imbalance seen in patients with MF and results in an increase of Th1 cytokines. Clinicians should consider more frequent use in select patients
Lasers in melanoma careLaser for melanoma in situ (MIS) should generally be reserved for nonsurgical, usually elderly patients. When indicated, MIS may be treated with CO2 laser or with combined Q-switched Nd:YAG and imiquimod. Any atypical-appearing lesion should be biopsied prior to the start of a laser treatment.
Skin cancer advancesGenetic profiling is valuable in both diagnosis and prognosis of skin cancer. Hedgehog inhibitors and (superficial radiation therapy) SRT are strong contenders for treating nonmelanoma skin cancer. Advances in targeted therapies and biologics are part of the new wave of melanoma treatments.
Derm sounds alarm about Hispanics and skin cancerDermatologists should be versed and informed about the specific attitudes and lifestyle habits that could be fueling rising skin cancer risk in the Hispanic population, according to dermatologist Maritza I. Perez, M.D.
Psoriasis and skin cancerCyclosporine and PUVA clearly increase the risk of squamous cell carcinomas, and there is evidence that TNF blockers and methotrexate may do so to a lesser degree. UVB phototherapy has not been shown to cause skin cancer. Acitretin offers protection against the development of basal cell and squamous cell carcinomas.
SRT: Technology offers positive benefits and strong cure ratesToday’s SRT technology embodies very small, stable machines. Radiation leaks are not longer a concern. The SRT-100 System serves both an important medical and cosmetic role.
Skin cancer screenings targeting “right” peopleAbout one third of the more than 118,000 people who received free skin cancer screenings from the AAD’s SPOTme program in 2009 and 2010 indicated they had recently seen a change in the size, shape or color of a mole.
First drug for rare skin cancer wins approvalFDA approved the first treatment for metastatic Merkel cell carcinoma (MCC), a rare, aggressive skin cancer.

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