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    When other treatments fail in atopic dermatitis, dupilumab succeeds

    Dupilumab plus topical corticosteroids safe and effective after failure of cyclosporine in moderate-to-severe atopic dermatitis

     

     

    IN SUMMARY

    • Dupilumab combined with topical corticosteroids improved measures of overall disease severity vs placebo in patients who were inadequately controlled or intolerant of CSA, or did not receive the immunosuppressive treatment due to medical concerns.
    • Conjunctivitis was more frequent in patients who received dupilumab with TCS, but overall, the proportion of patients reporting an adverse event was similar among dupilumab and placebo arms.
    • Dupilumab plus TCS may be a good alternative to CSA in this difficult-to-treat population for whom there are few treatment options.

     


    DISCLOSURES:

    Dr. Thaçi reports he has been investigator, member of medical advisory board, and speaker for Regeneron/Sanofi.

     

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