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    Path to cure port-wine stains

     

    Drug/device combination treatment

    Other treatment approaches include the targeting of the feeder vessels that, in part, serve as a pipeline for these vascular malformations, as well as drug and device combination therapies. Port-wine stain vessels lack normal sympathetic tone. One potential example of a drug/device combination would be to treat with a laser and a medication to address the neural deficit. Other examples of medications that may be useful in conjunction with laser and light sources are angiogenesis inhibitors, photosensitizers implemented with photodynamic therapy, or drugs with molecular targets based on genetic mutations. These approaches could increase the long-term therapeutic outcomes of PWS.

    “The ultimate vision and goal is a single laser treatment at an early age. This is not just a cosmetic issue. We know that the majority of port-wine stains hypertrophy, and that can lead to functional issues in addition to the disfigurement and social distress that port-wine stains can cause. In full disclosure, I don’t know if we can cure port-wine stains. We owe it to our patients to try to do better and apply these new strategies that could be a part of that path to a cure for PWS,” Dr. Rubin says.

     

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