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    Path to cure port-wine stains


    Heart attack for the skin

    Clipping off an artery with a laser can be likened to a heart attack for the skin where necrosis and scarring can ensue. One of the benefits of vein selective photothermolysis would be that potentially, one could have a more safe and effective treatment by avoiding the arteries and arterioles and only selectively targeting the venules. Targeting the venules could potentially also help reduce the hypoxic stimulus and angiogenesis often seen following traditional laser therapy, and result in a higher efficacy and efficiency of PWS treatment.

    Using multiple pulses, multiple passes, and tailoring the pulse duration, are other smart strategies that can help improve outcomes in PWS treatment. Employing multiple pulses can increase the depth of penetration, and a lower radiant exposure is required for each pass. According to Dr. Rubin, one of the main limitations with pulsed dye is that the depth of penetration is less than some port-wine stains require.

    “Physicians typically treat port-wine stains with a single pulse duration, however port-wine stains can be heterogeneous, composed of vessels of various sizes. What if we had a smarter laser that could vary the pulse duration as it moved along to match the size of the vessels? A tailored pulse duration throughout the treatment would be a significant procedural benefit, treating vessels of all sizes,” she says.

    Next: Drug/device combination treatment


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