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    Path to cure port-wine stains


    Treatment strategies

    There are a number of treatment strategies, Dr. Rubin says, many of which are still under conception that could significantly impact treatment outcomes of PWS. According to Dr. Rubin, one solution would be the use of smarter lasers, which could generate pre-treatment road map imaging of the lesion, and allow clinicians to tailor treatment parameters optimizing wavelength, pulse duration and fluence to the specific vascular lesion to be treated.

    “Ideally, it would be much smarter if we had a way to get a road map before we went and treated with a laser. Here, an imaging modality can be used to visualize the vessels in real-time, allowing the clinician to appropriately tailor the laser parameters specific to the targeted vessels,” Dr. Rubin says.

    Vein selective photothermolysis would be another new approach that could more effectively address PWS. Port-wine stains are composed of post-capillary venules and targeting venous blood could perhaps improve treatment efficacy and safety. According to Dr. Rubin, in vitro studies suggest the 680 nm wavelength to be optimal for venous selectivity by maximizing Hb/HbO2 and Hb/metHb.

    “When we think about targeting blood, the traditional target has been oxyhemoglobin, but veins have both deoxyhemoglobin and oxyhemoglobin. So, if you want to selectively target the veins and avoid the arteries, you can do that by going after deoxyhemoglobin,” she says.

    Next: Heart attack for the skin


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