Oral medication clears senile purpura
Boynton Beach, Fla. — A new experimental oral medication known as Purpurex (New Vitality) is effective in improving and even clearing the appearance of senile purpura, while helping to prevent new lesions from occurring, according to a recent study.
Thought to be due to an increased weakening in the connective tissues and blood vessels, senile — or Bateman's — purpura is a chronic condition commonly seen in individuals over age 50. Characterized by dark purple blotches of irregular form and size, the benign lesions are purely cosmetic lesions and typically a source of embarrassment.
"Patients with senile purpura (SP) tend to bruise very easily and develop ecchymoses appearing most commonly on the extensor surfaces of the forearms, legs and hands following suspected trauma to those areas. Until now, no effective treatments have been available to address the condition, let alone help prevent future lesions from occurring," says Joshua M. Berlin, M.D., Dermatology Associates P.A., Boynton Beach, Fla.
Dr. Berlin recently conducted a clinical trial evaluating the efficacy and safety of Purpurex in improving the skin's appearance in patients with SP. In the multicenter, randomized, placebo-controlled, double-blind study, 70 patients with SP were enrolled, of which 67 completed the trial.
Patients were randomized to receive either Purpurex, which consists of a nutraceutical citrus bioflavonoid blend (CBB) of ingredients, or placebo (calcium carbonate) twice daily in oral form for six weeks. A representative area of skin bruising located on either the right or left forearm, hand or leg was selected from each patient and its appearance documented with a high-resolution digital photograph.
Patients were assessed at baseline, two, four and six weeks.
Participants were permitted to take warfarin, clopidogrel or aspirin during the study if they were on these medications previously.
At the six-week follow up, a 50 percent reduction in the purpura lesions from baseline was seen in those patients receiving Purpurex, compared to a 9 percent increase in purpura lesions in the placebo group. Those patients receiving Purpurex showed a 19 percent, 29 percent and 50 percent decrease in purpura lesions at weeks two, four and six, respectively. No adverse effects were noted in both study arms by either the patients or the investigators.
"We believe that the steady decrease in the number of purpura lesions is due to a cumulative pharmacological effect of the supplement, the ingredients of which work synergistically to improve the appearance of SP and prevent new lesions from forming," Dr. Berlin says.
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