• linkedin
  • Increase Font
  • Sharebar

    Melanoma research roundup

     

    (Designer491Shutterstock.com)

     

    Dermatomyositis increasingly failing treatment

    Researchers writing in JAMA Dermatology find that most adult patients with dermatomyositis do not achieve satisfactory control of this disease, even with long-term aggressive therapy.

    Dermatomyositis is an idiopathic inflammatory myopathy that manifests as inflammation of the skin, muscles, joints and lungs. It can lead to organ damage with extensive cutaneous disease. The skin is affected in cases of patients with classic myositis, patients who are clinically amyopathic, in patients who never develop muscle disease, and patients with persistent skin inflammation.

    The goal of this study was to characterize the cutaneous disease course in adult patients.

    Of 74 patients included in this prospective cohort study, 28 patients achieve clinical skin remission in a three-year follow-up period.

    “Increasing age, having an associated malignancy, and treatment with mycophenolate mofetil were significantly associated with clinical remission of skin disease, while having anti–melanoma differentiation-associated gene 5 antibodies was significantly associated with worse outcomes,” researchers wrote.

     


    REFERENCE

    Paige W. Wolstencroft, BA; Lorinda Chung, MD, MS; Shufeng Li, MS; et al. “Factors Associated With Clinical Remission of Skin Disease in Dermatomyositis,” JAMA Dermatology, online first, Nov. 7, 2017. DOI: 10.1001/jamadermatol.2017.3758

     

     

     

     

     

     

                                                                                                                                                                         

    0 Comments

    You must be signed in to leave a comment. Registering is fast and free!

    All comments must follow the ModernMedicine Network community rules and terms of use, and will be moderated. ModernMedicine reserves the right to use the comments we receive, in whole or in part,in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.

    • No comments available
    Derm Pulse
    Article image

    ©TED

    Brought to you by:

    Ortho Derm

    Latest Tweets Follow