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    Isotretinoin’s discovery and development

    Expert discusses pearls gleaned from initial clinical observations

     

    References:

     

    [1] Gentles JC. Experimental ringworm in guinea pigs: oral treatment with griseofulvin. Nature. 1958;182(4633):476-7.

    [2] Peck GL, Olsen TG, Yoder FW, et al. Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid. N Engl J Med. 1979;300(7):329-33.

    [3] Strauss JS, Rapini RP, Shalita AR, et al. Isotretinoin therapy for acne: results of a multicenter dose-response study. J Am Acad Dermatol. 1984;10(3):490-6.

    [4] Leyden JJ, Del rosso JQ, Baum EW. The use of isotretinoin in the treatment of acne vulgaris: clinical considerations and future directions. J Clin Aesthet Dermatol. 2014;7(2 Suppl):S3-S21.

     

    Elaine Siegfried, M.D.
    Elaine Siegfried, M.D., is professor of pediatrics and dermatology, Saint Louis University Health Sciences Center, St. Louis, Mo. She ...

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