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    Parasites and inflammation fuel rosacea

     

    Disclosure: Dr. Gooderham has been a speaker and investigator for Galderma.

    References:

    1. Yamasaki K, Kanada K, Macleod DT,  et al. TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes.  J Invest Dermatol. 2011;131(3):688-97.

    2. Casas C, Paul C, Lahfa M, et al. Quantification of Demodex folliculorum by PCR in rosacea and its relationship to skin innate immune activation. Exp Dermatol. 2012;21(12):906-10.

    3. Aldrich N, Gerstenblith M, Fu P, et al. Genetic vs. Environmental Factors that Correlate with Rosacea: A Cohort-Based Survey of Twins. JAMA         Dermatol. 2015 Aug 26.

    4. Bahadoran P. Br J Dermatol. 2015;173(1):8-9.

    5. Stein L, Kircik L, Fowler J, et al. Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies. J Drugs Dermatol. 2014; 13(3):316-23.

    1. Stein Gold L, Kircik L, Fowler J, et al. Long-term safety of ivermectin 1% cream vs. azelaic acid 15% gel in treating inflammatory lesions of rosacea: results of two 40-week controlled, investigator-blinded trials. J Drugs Dermatol. 2014;13(11):1380-6.

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