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CLINICAL

March Clinical Considerations for NPs, PAsThis month we’re looking at some allergy guideline recommendations, discuss whether or not ‘natural’ soap is milder and novel immunomodulaters.
Brodalumab approved for psoriasisDr. Mark Lebwohl talks about the FDA’s approval of the anti-interleukin-17 receptor monoclonal antibody brodalumab (Siliq, Valeant Pharmaceuticals) for treatment of adults with moderate-to-severe plaque psoriasis.
Psoriasis underdiagnosed, undertreatedIn skin of color, psoriasis can be tough to spot, and it carries a broader differential diagnosis. Darker-skinned patients may not know that they can develop psoriasis, or the importance of seeking treatment early.
Research gaps persist in psoriasis, psoriatic arthritisBeing able to predict which patients will respond to which treatments will help dermatologists in treating psoriasis, preventing progression to psoriatic arthritis and reducing comorbidities.
Genetic insights inform autoinflammatory therapiesKnowing the genetic basis of monogenic skin diseases may one day help dermatologists treat non-monogenic skin diseases as well.
A new era in atopic derm treatment
A new era in atopic derm treatmentPromising new treatments recently approved or under development for atopic dermatitis include crisaborole, JAK inhibitors and dupilumab, an expert said.
Pruritic vesicles erupt on a boy’s legsA healthy 12-year-old boy with eczema shows up at the office with an incredibly itchy rash on his legs that has exploded over the last 48 hours. He has a history of dry skin to which his mother regularly applies various moisturizers, including calendula oil.
Two-step egg introduction helps prevent egg allergyStepwise introduction of egg (starting with a low dose, which is then increased), along with aggressive treatment of atopic dermatitis (AD), is a safe and effective way to prevent hen’s egg allergy in high-risk infants, a study in Japan showed.
Psoriasis drug approved with boxed warningA new drug to treat moderate-to-severe plaque psoriasis carries a black box warning that suicidal ideas and behavior, including completed suicides, have occurred in patients during the drug’s clinical trials.
Practice gaps in childhood acne treatmentCombination therapies are under used; the role of diet, while controversial, may be beneficial; and, cosmeceuticals may remedy mild-to-moderate acne. Read more on acne treatment guidelines.

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