CLINICAL

Microbe imbalance fuels acneThe difference between acne and healthy skin is largely dependent on the balance of the skin microbiota, according to study results.
New treatments on the horizonEmerging therapies are showing impressive efficacy and good tolerability, according to one dermatologist.
Laser treatments found safe, effectiveA new study finds that use of dual laser therapy alone in skin types V and VI achieves excellent results with an exceptional side-effect profile.
Office-based alternative to in-home oral and topical regimenApplication of a topical photoparticle immediately before non-ablative 810 nm diode laser treatment for acne resulted in a statistically significant reduction from baseline in inflammatory acne counts on the back, according to a small feasibility study.
Autoimmune drug pipeline: What health execs should watchNew drugs for RA, psoriasis, type 1 diabetes and Crohn’s disease—some recently approved and others coming down the pipeline—could have an impact on the industry.
Study finds significant inpatient burden for AD patientsA recent study looked at the inpatient burden on patients with atopic dermatitis (AD) in the United States and found a significant financial burden due to the high hospitalization rates.
Hormonal therapies effective for acneHormonal therapies are an effective strategy to improve acne in women but some of these treatments, including birth control pills, are not commonly prescribed.
Isotretinoin still the best drug for acne
Isotretinoin still the best drug for acneAs part of its updated guidelines for the treatment of acne published early last year, the American Academy of Dermatology included new recommendations for the use of oral isotretinoin.
A new class steps forwardPhosphodiesterase (PDE) inhibitors including apremilast and crisaborole ointment may provide safer alternatives than traditional steroid-sparing agents for psoriasis and atopic dermatitis. Side effects of apremilast may include GI symptoms, weight loss and depression, and taking apremilast with anti-seizure drugs or rifampin lowers apremilast blood levels, Apremilast is being studied in inflammatory bowel disease, Behcet's disease and pediatric psoriasis, and may have a place in the treatment of hidradenitis suppurativa (HS).
TNF inhibitor treatment tacticsWith a long history in dermatology and rheumatology, TNF inhibitors can not only improve psoriasis and psoriatic arthritis, but they also may reduce comorbid cardiovascular risks and work better combined with methotrexate. Low doses of cyclosporine may be effective at treating the psoriasis reaction when topicals have proven ineffective. Aggressively managing TNF-induced reactions can help patients stay on drugs that are working for other challenging diseases.

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