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John Jesitus
John Jesitus is a medical writer based in Westminster, CO.
The feminine mystique
Surgical and nonsurgical options provide effective treatment for the growing number of women seeking vaginal rejuvenation, experts say.
A new class steps forward
Phosphodiesterase (PDE) inhibitors including apremilast and crisaborole ointment may provide safer alternatives than traditional steroid-sparing agents for psoriasis and atopic dermatitis. Side effects of apremilast may include GI symptoms, weight loss and depression, and taking apremilast with anti-seizure drugs or rifampin lowers apremilast blood levels, Apremilast is being studied in inflammatory bowel disease, Behcet's disease and pediatric psoriasis, and may have a place in the treatment of hidradenitis suppurativa (HS).
TNF alfpha inhibitor safety, efficacy data grows
Long-term follow-up studies and drug registries continue to deliver reassuring data regarding the safety and efficacy of TNF inhibitors, an expert says.
TNF inhibitor treatment tactics
With a long history in dermatology and rheumatology, TNF inhibitors can not only improve psoriasis and psoriatic arthritis, but they also may reduce comorbid cardiovascular risks and work better combined with methotrexate. Low doses of cyclosporine may be effective at treating the psoriasis reaction when topicals have proven ineffective. Aggressively managing TNF-induced reactions can help patients stay on drugs that are working for other challenging diseases.
Psoriasis underdiagnosed, undertreated
In skin of color, psoriasis can be tough to spot, and it carries a broader differential diagnosis. Darker-skinned patients may not know that they can develop psoriasis, or the importance of seeking treatment early.
Research gaps persist in psoriasis, psoriatic arthritis
Being able to predict which patients will respond to which treatments will help dermatologists in treating psoriasis, preventing progression to psoriatic arthritis and reducing comorbidities.
PDT addresses '50 shades of solar damage'
PDT is underutilized as field treatment for AKs. An expert pushes for two to three hours' incubation time in her clinic and suggests efficacy-elevating pretreatment of lesions.
Genetic insights inform autoinflammatory therapies
Knowing the genetic basis of monogenic skin diseases may one day help dermatologists treat non-monogenic skin diseases as well.
Apps distract patients from procedure pain
Taking the sting and stress out of dermatologic procedures requires low-tech distraction techniques and, often in the case of children, amusing apps.
2016 studies highlight adjuvant zoster vaccine, UV protection
Important recent publications from mainstream medical journals highlight the following: Automobile side windows do not block UV radiation well; An adjuvant herpes zoster vaccine works as well in patients over 70 years old as it did in the 50-plus age group; The American Academy of Ophthalmology recommends hydroxychloroquine and chloroquine dosing based on actual, not ideal, weight.

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