Barbara J. Rutledge, Ph.D.
Where to find a mouse model for dermatitis?
Washington - The availability of a suitable animal model for atopic dermatitis could advance research in the field and aid in the development of new therapies. Scientists in Japan may have developed such a model, according to Takuya Uozumi, MS, a researcher at Lion Corp.
'Critical for survival'
Amsterdam -- Combined use of an artificial skin substitute and stem cells may promote healing of difficult wounds, according to Sadanori Akita, M.D., Ph.D., senior assistant professor in the division of plastic and reconstructive surgery at Nagasaki University, Japan. "When dealing with serious wounds, such as extensive burn wounds, acceleration of wound healing is critical for survival," Dr. Akita said. "There is an unmet surgical need for better treatments for difficult wounds, especially in cases requiring resurfacing of large skin defects, and in contaminated or poorly vascularized wounds caused by irradiation or systemic diseases such as diabetics."
Over the rainbow
Barcelona - In two Phase IV efficacy studies designed to evaluate pimecrolimus 1 percent cream (Elidel?, Novartis Pharmaceuticals Corp.) under "real world" conditions, treatment with pimecrolimus 1 percent cream for up to six months was found to be safe and effective in infants, children, and adults who were suffering from atopic dermatitis with all degrees of severity and who had received a wide variety of previous treatments. Moreover, in both trials, subjects reported improvements in quality of life and a high degree of cosmetic acceptability, according to clinical investigators Lyn C. Guenther, M.D., F.R.C.P.C., Professor of Dermatology at the University of Western Ontario in London, Ontario, Can., and Sheila Fallon Friedlander, M.D., Associate Clinical Professor of Dermatology at Children's Hospital & UCSD Medical Center in San Diego, Calif. Results of both trials were presented at the 12th Congress of the European Academy of Dermatology and Venereology in Barcelona.
Invasion of neutrophils?
Richmond, Va. - Chronicity of nonhealing pressure ulcers appears to result from extensive invasion of neutrophils and destruction of growth factors, collagen, and other matrix components by neutrophil-derived enzymes, according to Robert F. Diegelmann, Ph.D., professor of biochemistry, anatomy, and emergency medicine at Virginia Commonwealth University in Richmond, Va.
Injury model designed
Amsterdam - Dermatologists have long been aware that superficial burns tend to heal quickly and leave little or no scarring, and that burns of full thickness, affecting deeper layers of the dermis, are often very slow to heal and leave permanent scars. According to Christopher Dunkin and Jonathon Pleat of the Stoke Mandeville Burns and Reconstructive Surgery Research Trust, Aylesbury, UK, the explanation for this difference might be that there is a "threshold level" for wound depth, with wounds above the threshold healing quickly without scarring and wounds below the threshold healing slowly and developing a fibrotic scar.
Malignant Wound Tx
Barcelona, Spain. - Treatments of malignant wounds should be designed not only to promote healing, but also to prevent and manage clinical infection, control and prevent bleeding, contain drainage from the wound, control and prevent odor, and promote the patient's comfort, according to Uwe Wollina, M.D., professor of dermatology and venerology at the Hautklinik Dresden-Friedrichstadt in Germany. Dr. Wollina spoke at the 12th Congress of the European Academy of Dermatology and Venereology in Barcelona.
Making Progress vs. HPV
Barcelona - Promising advances have been in the development of prophylactic vaccines targeting human papillomavirus (HPV), the major cause of cervical cancer and a possible contributing factor in non-melanoma skin cancers, according to Reinhard Kirnbauer, M.D., Associate Professor of Dermatology at the University of Vienna Medical School in Austria.
Anatomy of an Itch
Barcelona, Spain - A systematic approach is best when investigating patients who report itch but have no rash, according to Joanna Wallengren, M.D., Ph.D., associate professor in the department of dermatology, University Hospital in Lund, Sweden. Dr. Wallengren described her approach to this at the 12th Congress of the European Academy of Dermatology and Venereology here.
Grappling Gladiatorum
Minneapolis - To prevent outbreaks of herpes gladiatorum in high school athletes, closer scrutiny must be paid to prevention, diagnosis, and management of herpesvirus infections in this patient demographic, according to B. J. Anderson, M.D., Boynton Health Service, University of Minnesota, and team physician for the Augsburg College and University of Minnesota wrestling teams.
PLA Sheets Studied
Amsterdam - Second-generation PLA sheets dramatically inhibit wound contracture in the first three weeks and might have a useful role as a temporizing dressing for open wounds until skin grafts can be performed, according to Mayer Tenenhaus, M.D. FACS, who spoke at the 13th annual meeting of the European Tissue Repair Society. Dr. Tenenhaus is an assistant clinical professor of plastic and reconstructive surgery at the University of California at San Diego Medical School.

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