Barbara J. Rutledge, Ph.D.
Offer systemic therapy as first-line defense
Buenos Aires — In selecting therapies for patients with psoriasis, dermatologists need to consider that psoriasis is a life-long, systemic disease that substantially affects a patient's quality of life, according to Alan Menter, M.D., chief of the division of dermatology at Baylor University Medical Center, Dallas.
Pearls for facial wound reconstruction
National report — Reconstruction of facial wounds is excisional surgery that requires special attention to cosmetic outcome.
New advances offer insight about immune system
Buenos Aires, Argentina — Recent advances in the understanding of the skin immune system are represented in four major areas of research: Langerhans cell trafficking, innate immunity, complex genetic diseases with an immunologic basis and psoriasis, according to Stephen I. Katz, M.D., Ph.D., director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Md. Dr. Katz says, in each of these areas, there are potential therapeutic interventions.
Advances in deep mycosis continue
New Orleans — Dermatologists practicing medicine in tropical regions frequently treat fungal infections such as sporotrichosis, mycetoma and chromoblastomycosis — ailments that practitioners in temperate regions rarely encounter, according to Oliverio Welsh, M.D., emeritus professor, department of dermatology, Universidad Aut?noma de Nuevo Le?n, Monterrey, Mexico. Superficial skin infections are the most common fungal infections, but subcutaneous infections, known as deep mycosis or, in rare cases, disseminated fungal disease, may also occur.
Trial HSV-2 vaccines show promise
Washington — Clinical studies have already demonstrated proof of concept for both prophylactic and therapeutic vaccines for herpes simplex virus (HSV)-2. Both types of HSV-2 vaccines are currently under development and the next few years should bring promising results, accordingto Lawrence R. Stanberry, M.D., Ph.D., chairman of the department of pediatrics and director of the Sealy Center for Vaccine Development at the University of Texas Medical Branch in Galveston.
The odd couple of viruses — HIV-1 and HSV-2
Washington — Although HIV-1 and HSV-2 are unrelated viruses, differing greatly in structure, size, mode of replication, mechanism of action and other criteria, there exists an epidemiological symmetry between the two viruses.
Novel cephalosporin fights MRSA
Washington — Promising results were seen in a phase 2 trial of the first drug in a new class of cephalosporins active against multi-drug resistant Staphlococcus aureus, according to Markus Heep, M.D., medical microbiologist and project physician at Basilea Pharmaceutica, Ltd. in Basel, Switzerland.
Argentine dermatologists target psoriasis, leprosy, skin cancer
Buenos Aires — "Controle sus lunares por una piel sana" (control your moles for a healthy skin) is a message that people throughout Argentina heard repeatedly last November, thanks to the efforts of Rebeca Rubinson, M.D., and her colleagues at the Sociedad Argentina de Dermatologia (SAD) here. Dr. Rubinson is a pediatric dermatologist affiliated with Hospital Abel Zubizarreta in Buenos Aires and the coordinator of the 2004 campaign on recognition and prevention of skin cancer.
Understanding mechanisms of aging in skin
Singapore — To understand the aging process and its effect on the skin, it is useful to consider three categories of aging: the normal aging process, premature aging associated with genetic disorders and aging resulting from environmental damage, according to Chikako Nishigori, Ph.D., M.D., professor and chairman of the division of dermatology, Kobe University Graduate School of Medicine, Hyogo, Japan. Among environmental causes of premature aging, the long-term effects of repeated exposure to UV are the most significant, leading to photoaging.
Target four-to-eight-week tx window to minimize formation of scar tissue
To minimize scar formation, intercept facial wounds as early as possible, and treat them during the four-to-eight-week window after the trauma or incision, advises Joseph Niamtu III, D.M.D., an oral/maxillofacial and cosmetic facial surgeon based in Richmond, Va.

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