Wayne Kuznar
Inflammatory pathway to diabetes may be interrupted by salicylates
Salsalate may represent a novel treatment to lower blood glucose in patients with type 2 diabetes. Promising results from the dose-ranging first stage of the Targeting Inflammation Using Salsalate for Type 2 Diabetes (TINSAL-T2D) study support the larger stage 2 of the study to evaluate the effects of salsalate on blood glucose control over 48 weeks.
Switching from exenatide to investigational GLP-1 analog improves glycemic control with low risk of hypoglycemia
Switching from twice-daily exenatide to the investigational once-daily liraglutide improves glycemic control in patients with type 2 diabetes on a background of metformin and/or a sulfonylurea.
No advantage to revascularization over optimal medical therapy in patients with type 2 diabetes and stable CAD
Prompt revascularization holds no advantage over optimal medical therapy in terms of survival among the overall population of patients with type 2 diabetes and stable coronary artery disease (CAD).
New form of inhaled insulin controls postmeal glycemia with minimal weight gain
An investigational ultra rapid-acting inhalable insulin (Technosphere™ Insulin) at mealtime in combination with basal insulin in patients with type 2 diabetes has glycemic efficacy over 52 weeks that is comparable to twice-daily premixed insulin analog 70/30 but with less risk of inducing weight gain and hypoglycemia, according to phase 3 data.
Potent antiplatelet therapy prevents stroke in AF when warfarin not used
Clopidogrel added to aspirin is superior to aspirin alone in preventing stroke in preventing vascular events, especially stroke, in patients with nonvalvular atrial fibrillation (AF) who are judged unsuitable for warfarin or are unwilling to take it.
Older heart failure patients rank survival over quality of life
Longevity trumps quality of life for most older patients with heart failure, found a study of end-of-life preferences of patients 60 years or older with heart failure.
Octogenarians who undergo CABG are living longer, feeling better
Advanced age does not exclude octogenarians from the potential benefits that accrue coronary artery bypass graft surgery.
Octogenarians also fare better after aortic valve replacement
The long-term survival for octogenarians who undergo aortic valve surgery approximates that of the general population, and the addition of coronary artery bypass graft (CABG) surgery diminished survivorship only slightly.
No effect of statin on cardiovascular outcomes in older patients with advanced systolic heart failure
In older patients with advanced systolic heart failure of ischemic etiology, rosuvastatin added to standard heart failure medication had no significant effect on the incidence of cardiovascular death, nonfatal MI, and nonfatal stroke compared with placebo.
Ranolazine reduces HbA1c levels in patients with diabetes
Ranolazine reduces HbA1c levels in patients with diabetes

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